General Synthetic Route to Monosubstituted Cycloheptadienes from Organometallic Compounds

An examination of the literature reveals that only a limited number of monosubstituted cycloheptadiene compounds have been reported. An obvious synthetic route to 5-substituted -1, 3-cycloheptadiene derivatives would be the reaction of nucleophiles with the cycloheptadienyl cation, but this pathway is generally unsuccessful due to the limited stability of the cation. On the other hand, the iron tricarbonyl complex of this cation shows remarkable stability¹ and an ability to react with nucleophiles². If the -Fe(CO)₃ group could be removed easily, a facile route to this family of organic compounds would be available. This work reports our investigation of the range of nucleophiles that can be utilized and the oxidizing agents that can remove efficiently the -Fe(CO)₃ group.     

缆机起重作业驾驶员的操作行为可靠性研究

缆机是大坝浇筑过程中的主要运输设备之一,缆机驾驶员操作水平直接关系缆机起重作业安全.为有效提高缆机起重作业驾驶员操作行为可靠性,预防起重作业安全事故,针对缆机起重作业周期性多维运动的特点,分解驾驶员操作流程;剖析操作行为失误,建立驾驶员行为模式;从时间角度量化操作流程,计算缆机驾驶员操作行为响应失误概率;构建操作行为可靠性分析模型,定量表达操作行为可靠性,分析人因失误对缆机起重作业安全事故的影响.结果表明,吊具与吊罐对接、混凝土卸料等作业过程的缆机驾驶员操作行为可靠性低,需加强安全培训,严格考核制度,从根本上提高缆机驾驶员操作行为的可靠性,以期提升缆机生产效率,实现预防安全事故的目标.     

Gold‐Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Two new gold‐catalyzed tandem cycloisomerization–halogenation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 3,3‐diiodopyrrolidin‐2‐ols and 3‐fluoropyrrolidin‐2‐ols were obtained in moderate‐to‐good yields with excellent enantio‐ and diastereoselectivity.     

The Construction of DNA Logic Gates Restricted to Certain Live Cells Based on the Structure Programmability and Aptamer-Cell Affinity of G-Quadruplexes

DNA computation is considered a fascinating alternative to silicon-based computers; it has evoked substantial attention and made rapid advances. Besides realizing versatile functions, implementing spatiotemporal control of logic operations, especially at the cellular level, is also of great significance to the development of DNA computation. However, developing simple and efficient methods to restrict DNA logic gates performing in live cells is still a challenge. In this work, a series of DNA logic gates was designed by taking full advantage of the diversity and programmability of the G-quadruplex (G4) structure. More importantly, by further using the high affinity and specific endocytosis of cells to aptamer G4, an INHIBIT logic gate has been realized whose operational site is precisely restricted to specific live cells. The design strategy might have great potential in the field of molecular computation and smart bio-applications.     

Enantioselective Cross-couplings between Halide Derivatives and Organometallics by Using Iron and Cobalt Catalysts: Formation of C−C Bonds

This review highlights the recent achievements of iron- and cobalt-catalyzed enantioselective cross-couplings of halide derivatives with organometallic reagents for the construction of C-C bonds. Synthetic applications of enantioselective cross-couplings to natural products and biologically active compounds are also covered showing the power of these cross-couplings in organic synthesis.